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technet21 postspacerReport on Intradermal Delivery of Vaccines

technet21 postspacerRedesigned Immunization Card

technet21 postspacerProgress Towards a Heat and Freeze–Stable Hepatitis B Vaccine
Issue 20, 14 September 2009

 
Editorial Note

Debra Kristensen posts a report assessing the potential of intradermal vaccine delivery. TechNet21 members are requested to send in their comments and suggestions.

Tasnim Partapuri shares a study that appeared in Vaccine on how an inexpensive and well–designed immunization card helps reduce vaccine dropouts. Since we are on the subject, do send in images of similar cards that are used in your countries and share related experiences in immunization record keeping.

Debra Kristensen also replies to Steven Wiersma's question regarding heat–stable second generation vaccines.

 by Debra Kristensen

We would like to share a report on intradermal delivery of vaccines that was commissioned by PATH's Disposable Jet Injector Project and Project Optimize ...

The purpose of the report is three–fold:

  1. To summarize the clinical evidence supporting the intradermal route for vaccine administration and the devices being developed for this purpose;
  2. To determine whether intradermal delivery broadly holds promise for vaccine applications for low– and middle–income countries in the future; and
  3. To begin to prioritize vaccine targets and device strategies that best fit the public health needs in these countries and likely merit further investigation.

[Read more]

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 by Tasnim Partapuri

In Pakistan, a small EPI card is used that contains information on the child identification; immunization schedule; information for mothers; and next immunization visit dates. All this information, cluttered on a small card, can make it difficult for generally less literate mothers to locate the item most relevant for them, i.e. their child's next immunization date. In addition, the next immunization date is handwritten and often in such small and irregular letters that it further amplifies the difficulty for mothers to read it. ...

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 by Debra Kristensen

Phase 3 bridging studies comparing the immunogenicity and safety of the new vaccine to the reference vaccine should be the norm to make these types of changes to second–generation vaccine products. We are looking at trials involving between 300 and 500 subjects. Yes, this is a costly endeavour. However, it is important that the stabilization methods be applied to at least a few existing products to pave the way for others.

[Read more]

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Inverted bottles
Photo Courtesy: ITPI
  
bottle in hand
Photo Courtesy: ITPI

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